| abstract |
There are disclosed compounds of the formula <IMAGE> wherein W represents a covalent bond or <IMAGE> X is N or CR2; Y is O, S, NR2 or C(R2)2 when n=0, or N or CR2 when n=1 Z is <IMAGE> +TR <IMAGE> R1 is hydrogen, lower alkyl, trifluoromethyl, nitro, hydroxy, lower alkoxy, mercapto, loweralkylthio or halo; R2 is hydrogen or lower alkyl; n is 0-1; m is 1-6 with the proviso that m is 0-5 when W represents a covalent bond; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions. |