| abstract |
The compound of the formula <IMAGE> wherein R1 is hydrogen, methoxy or trifluormethyl, R2 and R3 are the same or different and are each hydrogen or methyl, R4 is a fluorinated lower alkyl having 2 to 5 carbon atoms and 1 to 11 fluorine atoms and X- is a pharmaceutically acceptable anion, respectively, possesses both strong antisecretory activity and gastric mucosal protective activity, which is produced by reacting a pyridine derivative of the formula <IMAGE> wherein R1, R2, R3 and R4 have the same meaning as defined above, with an acid. |