| abstract |
Benzimidazole derivatives of the formula (I): <IMAGE> (I) or a pharmaceutically acceptable acid addition salt thereof wherein R1 is hydrogen or lower alkyl; R2 is <IMAGE> or -C 3BOND C-Ar wherein Ar is phenyl unsubstituted or substituted by one to three substituents selected from the group consisting of halo, lower alkyl, hydroxy, unsubstituted or substituted lower alkoxy, aralkyloxy wherein the alkyl moiety is a lower alkyl moiety, lower alkenyloxy, lower alkynyloxy, difluoromethoxy, lower alkylamino, methylenedioxy, trifluoromethyl, cyano, lower alkylthio and lower alkylsulfinyl; R4, R5, R6 and R7 a hydrogen or lower alkyl or R4 and R5 together with the carbon atoms to which they are attached form a cyclopropyl ring; and R3 is hydrogen, lower alkyl, acyl or lower alkylsulphonyl are useful in the treatment of ulcers of the stomach and duodenum in humans and animals. |