| abstract |
Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-α-amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--αAbu--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or --Nva-- and Q=R 1 --CO--O--CH(R 2 )--CH(CO--)--NH-- wherein R 1 =H, C 1-4 alkyl or phenyl and R 2 =H or CH 3 , possess immunosuppressive, anti-inflammatory and anti-parasitic activity. |