| abstract |
Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R 5 wherein R 1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R 4 and R 5 are both hydrogen or together form a single chemical bond, n R 2 and R 2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, and n R 3 and R 3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R 2 and R 2 ' cannot be both hydrogen, n and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R 5 wherein R 4 and R 5 together form a single chemical bond, R 1 is unsubstituted aryl and R 2 and R 2 ' are both hydrogen, then R 3 and R 3 ' are independently carboxy or its functional derivative other than methyl ester, are novel. |