| abstract |
Histaminic H 1 -receptor antagonists of the formula: ##STR1## in which R 1 is ##STR2## where R 2 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo, nitro, cyano or trifluoromethyl; and R 3 is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo, nitro, cyano or trifluoromethyl; n X is hydrogen, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms or halo; n Z is ##STR3## where R 4 is pyridinyl, quinolinyl or benzoyl, any of which may be substituted by alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo or trifluoromethyl; and m is one of the integers 2, 3 or 4; and n n is one of the integers 1, 2, 3 or 4; n or a pharmaceutically acceptable salt thereof. |