http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4751305-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1987-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f30bd3f4a63a166dd10fe3a74ba9341b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_071bf4cb22ddb55ababefcd6af916ad4 |
| publicationDate | 1988-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4751305-A |
| titleOfInvention | 2-heterocyclobenzo[B][1,6]naphthyridines as inhibitors of interleukin |
| abstract | There are disclosed compounds of the formula <IMAGE> wherein R1 is pyridl, quinolinyl, pyrazinyl, pyridinyl, pyridazinyl, pyrimidinyl, quinoxalinyl, quinazolinyl or any of the foregoing substituted with halo, lower alkyl, lower alkyl carbonyl, benzoyl, carboxy, lower alkoxycarbonyl, OR2, N(R2)2, CON(R2)2, SO3R2, SO2N(R2)2, phenylsulfonyl, lower alkylsulfonyl, cyano, nitro or trifluoromethyl; R2 is hydrogen, lower alkyl or phenyl; R3 is halo, morpholino, 4-methylpiperazino, R4NNHR5, NR4R5, OR5, SR5, R4NCH2CH2OCH3, SCH2CH2CH2NH2, or <IMAGE> R4 is hydrogen or lower alkyl; R5 is hydrogen, lower alkyl, lower alkanoyl, lower cycloalkylor phenyl; and R6 and R7 are each independently, hydrogen, halo, nitro, lower alkoxy, lower alkyl, cyano, trifluoromethyl, phenyl, carboxy or lower alkoxycarbonyl; which, by virtue of their ability to inhibit interleukin 1, are of use as antiinflammatory agents and in treatment of disease states involving enzymatic tissue destruction, and are also intermediates in the preparation of other compounds which possess identical activities. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5039521-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011116867-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4851536-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5256411-A |
| priorityDate | 1987-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 120.