| abstract |
The invention provides a conjugate comprising an enzyme having its antigenic sites or antigenicity masked by albumin and having a targeting agent attached, and a method for its preparation. The albumin is included in an amount sufficient to mask antigenicity of the enzyme. The targeting agent used has binding specificity for receptor sites on cells towards which it is desirable to direct the enzyme. Insulin, immunoglobulin G, antibody against human pancreatic tumor cell, and antibody against hyaluronic acid are exemplified as targeting agents. |