http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4746649-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-86 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0227 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 |
| filingDate | 1987-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19015e9ab9912772df810ac7b859b22c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed01196e120e6b2a6f541079e1f23f30 |
| publicationDate | 1988-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4746649-A |
| titleOfInvention | Diamino acid derivatives |
| abstract | New diamino acid derivatives of the formula I n n X--Z--NH--CH(CH.sub.2 R.sup.1)--CH(NH.sub.2)--CH.sub.2 --CO--E--G--Y I n n wherein n X is H, R 2 --O--C n H 2n --CO--, R 2 --C n H 2n --O--CO--, R 2 --C n H 2n --CO--, R 2 --SO 2 , (R 2 --C n H 2n )--L(R 2 --C r H 2r )--C t H 2t --CO--, H--(NHCH 2 CH 2 ) n --NH--CH 2 CO-- or 9-fluorenyl--C n H 2n --O--CO--, n Z is 0 to 4 amino acid radicals, bonded to one another in a peptide-like manner, selected from the group consisting of Abu, Ada, Ala, Arg, Dab, Gly, His, Ile, Leu, tert.-Leu, Lys, Met, Nbg, Nle, N-Me-His, N-Me-Phe, Orn, Phe, Pro, Ser, Thr, Tic, Trp, Tyr and Val, n R 1 is H, A, cycloalkyl with 3-7 C atoms, Ar or C p H 2p --W, n E is absent or is Ala, Gly, Ile, Leu, tert.-Leu, Met, Ser, Thr or Val, n G is absent or is His, Phe, Trp, Tyr or --NH--CH(CH 2 R 1 )--CH(NH 2 )--CH 2 CO--, n Y is --O--C m H 2m --R 3 , --NH--C m H 2m --R 3 , --NH--C m H 2m-1 (R 3 ) 2 or NA 2 , n R 2 is A, cycloalkyl with 3-7 C atoms, benzyl or Ar, n L is CH or N, n R 3 is H, A, cycloalkyl with 3-7 C atoms, Ar, pyridyl, imidazolyl, piperidyl, N-benzyl-piperidyl or piperazinyl, n W is OH, NH 2 , OA, NHA or NA 2 , n A is alkyl with 1-6 C atoms, n Ar is unsubstituted phenyl, phenyl which is mono- or polysubstituted by A, AO, F, Cl, Br, I, CF 3 and/or NH 2 , or unsubstituted naphthyl and n m, n, p, r and t are each 0, 1, 2, 3, 4 or 5, and salts thereof, n inhibit the activity of human plasma renin. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7973008-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5057496-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8263548-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8188215-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4985407-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7632803-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005215468-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003130185-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003158111-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7592304-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8017728-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4826958-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011212903-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011212902-A1 |
| priorityDate | 1984-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 683.