http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4746516-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 1986-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1988-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_268b59ab91f68a6326ab91203d3804f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26e0968864c5e4d6ac8a816d0049e15e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a512e8e9b4adfc171843ae714b973fda |
| publicationDate | 1988-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4746516-A |
| titleOfInvention | Pharmaceutical compositions consisting or consisting essentially of freeze-dried drug-carrying liposomes |
| abstract | A method is disclosed for purifying non-homogeneous systems, known as liposomic suspensions, from non-entrapped drugs wherein said suspensions are treated with liquid or solid polymers of synthetic and organic nature having chemical functionality, which are used as ion-exchangers. The liquid or solid polymers are based on styrene, divinylbenzene, acrylic acid, methacrylic acid, and the like, normally known as ion-exchange resins, and may include carboxylic, phosphonic or sulphonic functions of different matrices. The ion-exchange resins may also include salified quaternary ammonium, primary, secondary and tertiary amminic or phosphinic functions or other functions with different matrices, including phenolformaldehyde, styrene-divinylbenzene, acrylates, methacrylates, hydrocarbons and condensation-resins. Treatment may also be carried out with polymers, copolymers, or mixtures thereof, not having any specific chemical function and which normally, but not exclusively, react according to Van der Waals' forces, commonly known as adsorbents. The invention also includes freeze-dried pharmaceutical compositions consisting or consisting essentially of lyophilic liposomes of drugs, such as doxorubicin hydrochloride, aminosidine sulphate or 5-fluoro-uracil. The pharmaceutical compositions are characterized by a high degree of stability. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5589189-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4873088-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107285-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0834309-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4906477-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5540936-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4906476-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5817334-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004109826-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0834309-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004023935-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6033708-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005058605-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5043165-A |
| priorityDate | 1977-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.