| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0679 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 |
| filingDate |
1984-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1988-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01f53ef7ff9fec3c29a21787b849d50c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80186e5b02571f240b68ce259a659ae3 |
| publicationDate |
1988-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4743552-A |
| titleOfInvention |
Method for growth in tissue culture of normal colonic epithelial cells and method for determination of preneoplastic color cells |
| abstract |
The invention concerns a method for the routine primary culture of human colonic epithelial cells within a monolayer. 12-0-tetradecanoylphorbol-13-acetate (TPA) enhanced DNA synthesis an average of 8 fold when assayed by [3h]dThd labeling indices (L.I.) in colonic epithelial cells from familial polyposis patients and in tubular adenomas. No such stimulation by TPA was seen in cells from high-risk patients without familial polyposis, or in cells from low-risk subjects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003064056-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7247481-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6696270-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5753267-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7175841-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9739109-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6087157-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8765464-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005025838-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6375989-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6485723-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9624661-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004157283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003194805-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2757536-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011165126-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7771717-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008014637-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11478574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8647677-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5866414-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2747395-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8409625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007141037-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5695998-A |
| priorityDate |
1984-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |