| abstract |
There are disclosed compounds having the formula <IMAGE> wherein X is CR or N when n=1; or X is O, S, NR or CR when n=0; R is hydrogen or lower alkyl; Y is -CH2-, -S-, -O- or <IMAGE> and A is <IMAGE> Z is CH or N; R1 is halo or trifluoromethyl; R2 is hydrogen or halo; R3 is hydrogen or halo; with the proviso that when A is naphthyl, Y is -O- and n=0, X is other than S; and their use in the treatment of inflammatory conditions and in the treatment of leukotriene-medicated naso-bronchial obstructive passageway conditions. |