abstract |
The compounds represented by the following structural formula (I) <IMAGE> (I) wherein m is 1 or 2; n is 1, 2 or 3; R' is hydrogen or methyl; R is a radical selected from the group consisting of: <IMAGE> wherein R1 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxypentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C4 to C10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C3 to C9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH=CH-(CH2)2-8, phenyl-C3 to C9 alkoxy, trifluoromethyl-C7 to C12 alkyl, cyclohexyl- C4 to C10 alkyl or <IMAGE> wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and R2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R1 is hydrogen and R2 is C8 to C13 alkyl, C7 to C12 alkoxy, C7 to C12 thioalkyl, C10 to C12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxy(pentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C4 to C10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C3 to C9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH=CH-(CH2)2-8, phenyl-C3 to C9 alkoxy, trifluoromethyl-C7 to C12 alkyl, cyclohexyl-C4 to C10 alkyl or <IMAGE> wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and p is 0 or 1, with the proviso that R is not a thiophene radical and any of R1 and R2 above are not thioalkyl or phenylthioalkyl when p is 1; and pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma. |