| abstract |
A method of treatment of emesis, anxiety and/or IBS in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof: n n Ar--Co--Y--Z (I) n n wherein Ar is a group of formula (a): ##STR1## wherein: R 1 and R 2 are independently selected from hydrogen, halogen, C 1-6 alkyl, C 1-4 alkoxy, hydroxy, amino optionally substituted by one or two C 1-4 alkyl groups, thiol, C 1-4 alkylthio; X is CH 2 , NR 3 , --O-- or --S-- wherein R 3 is hydrogen, C 1-4 alkyl, C 3-5 alkenyl, phenyl or phenyl C 1-4 alkyl; or Ar is a group of formula (b): ##STR2## wherein R 4 to R 7 are independently hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, hydroxy, amino optionally substituted by one or two C 1-4 alkyl, by C 1-4 alkanoylamino or pyrrolyl, one of R 4 to R 7 being other than hydrogen; n Y is --O-- or --NH--; and n Z is a group of formula (c), (d) or (e): ##STR3## wherein n is 2, 3 or 4; n R 8 is hydrogen, C 1-7 alkyl, C 3-5 alkenyl or phenyl C 1-4 alkyl optionally substituted by one or two halogen, C 1-4 alkoxy or C 1-4 alkyl; ##STR4## wherein: p is 1, 2 or 3; and n R 9 is as defined above for R 8 ; n and with the proviso that, when Ar is of formula (b) and Y is --NH--, Z is a group of formula (d) or (e); ##STR5## wherein R 10 is hydrogen, C 1-10 alkyl, C 3-7 cycloalkyl, C 3-6 alkenyl, phenyl or phenyl-C 1-3 alkyl; and n one of the groups represented by R 11 , R 12 and R 13 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, C 2-6 alkenyl or phenyl-C 1-3 alkyl and each of the other groups, which may be the same or different, is hydrogen or C 1-6 alkyl. |