http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4714782-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-673 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-93 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-67 |
filingDate | 1985-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 1987-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3062c15c22410c14d5c0cdb81a0aff5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f257e63f6f2ea4841148a14cac14be01 |
publicationDate | 1987-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-4714782-A |
titleOfInvention | Process for preparing optically active 4-hydroxy-2-cyclopentenones |
abstract | A process for preparing an optically active 2-substituted or unsubstituted-4-hydroxy-2-cyclopentenone of the formula: ##STR1## wherein R is a hydrogen atom, an allyl group or a propargyl group, which comprises reacting the corresponding 2-substituted or unsubstituted-4-hydroxy-2-cyclopentenone of the formula: ##STR2## wherein R is defined above with a lactone chosen from (1R,5S)-6,6-dimethyl-4-hydroxy-3-oxabicyc lo[3.1.0]hexan-2-one or (1S,5R)-6,6-dimethyl-4-hydroxy-3-oxabicyclo[3.1.0]hexan-2-one in a molar ratio of 1.5 - 2:1 in the presence of p-toluenesulfonic acid or benzenesulfonic acid in the coexistence of an organic solvent under elimination of water as an azeotropic mixture with the organic solvent to obtain a reaction mixture comprising (1R,5S)-6,6-dimethyl-3-oxa-4(R)-[1(R)-4-oxo-2-substituted or unsubstituted-2-cyclopentenyloxy]bicyclo[3.1.0]hexan-2-one or (1S,5R)-6,6-dimethyl-3-oxa-4(S)-[1(S)-4-oxo-2-substituted or unsubstituted-2-cyclopentenyloxy]bicyclo[3.1.0]hexan-2-one of the formula: ##STR3## wherein R is as defined above, of which either one isomer is contained in a considerably larger amount than the other isomer, separating the isom er having the larger content from the reaction mix ture and hydrolyzing the separated isomer to give the optically active 2-substituted or unsubstituted-4-hydrox y-2-cyclopentenone. |
priorityDate | 1984-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.