| abstract |
A compound of the formula <IMAGE> wherein T1 is lower alkylene, lower alkenylene or a single bond; X is <IMAGE> T2 is carbonyl, lower alkylene or a single bond; R2 is phenyl, phenoxy, pyridyl, pyrimidinyl, furyl, thienyl, lower cycloalkyl or adamantyl; R2 and R6, when taken together with the nitrogen to which they are attached form pyrrolidinyl, piperidinyl or azacyclooctanyl; R14 is COOR8 or -R3R9 wherein T3 is lower alkylene and R9 is lower alkoxy, lower cycloalkyl, cyano, polyfluoro-lower alkyl or pyridyl; and R1 and R5 are each lower alkyl or lower alkenyl, useful in the treatment of cardiovascular diseases. |