http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4692524-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79751aeaa9923745648e5ae7d9c35782 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-38 |
| filingDate | 1986-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7da786a489eb1e5d6b3d641f87d493f |
| publicationDate | 1987-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4692524-A |
| titleOfInvention | Process for the preparation of pyrimidine derivatives |
| abstract | The present invention relates to a process for the preparation of 2-mercapto-4,6-bis-fluoroalkoxypyrimidines of the formula ##STR1## wherein R 1 is C 1 -C 4 alkyl, phenyl or benzyl and each of T 1 and T 2 independently of the other is hydrogen or a --CHX 1 X 2 group, wherein each of X 1 and X 2 independently of the other is trifluoromethyl, fluorine, chlorine or bromine. n In accordance with this process, 2-mercapto-4-halo-6-hydroxy-pyrimidines of the formula ##STR2## wherein R 1 is as defined above and Y is chlorine or bromine, are reacted with chlorodifluoromethane or a 1,1-difluoroalkene of the formula ##STR3## wherein each of the X 1 and X 2 independently of the other is trifluoromethyl, fluorine, chlorine or bromine, in an inert solvent and in the presence of a strong base, to give a 2-mercapto-4-halo-6-fluoro-alkoxypyrimidine of the formula ##STR4## wherein R 1 , Y and T 1 are as defined above, said 2-mercapto-4-halo-6-fluoroalkoxypyrimidine is converted by subsequent reaction with an alkali metal nitrite or an alkaline earth metal nitrite into a 2-mercapto-4-hydroxy-6-fluoroalkoxypyrimidine of the formula ##STR5## wherein R 1 and T 1 are as defined above, and then said 2-mercapto-4-hydroxy-6-fluoroalkoxypyrimidine is converted by reaction with chlorodifluoromethane or a 1,1-difluoroalkene of the above formula into a 2-mercapto-4,6-bix-fluoroalkoxypyrimidine of the above formula. n The 2-mercapto-4,6-bis-fluoroalkoxypyrimidines of the above formula are intermediates for the preparation of herbicidally effective sulfonylureas. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5250689-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4900827-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5071982-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101456845-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5856483-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5064818-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0820992-A1 |
| priorityDate | 1986-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.