http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4672111-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_22af0c923d7537d54c62e7b66d4dceed |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1985-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb80d1777109f405f4cfb9d843a986f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d370fbe1a9471815aa71a028b81dca |
| publicationDate | 1987-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4672111-A |
| titleOfInvention | 5-azido-deoxyuridine compounds and method of synthesis of the same |
| abstract | 5-azido-2-'-deoxyuridine nucleoside and nucleotide compounds and a method of producing them. The method involves reacting a 5'-deoxyuridine compound with nitrosonium tetrafluoroborate to produce a 5-nitro-deoxyuridine compound. The 5-nitro-deoxyuridine compound is reduced to a 5-amino-deoxyuridine compound in the presence of metallic zinc. The 5-amino-deoxyuridine compound is acidified and reacted with sodium nitrite to produce a 5-diazo-deoxyuridine compound. The diazo-deoxyuridine compound is then reacted with sodium azide to produce a 5-azido-deoxyuridine compound. The latter, in the monophosphate form, is further reacted with diphenylchlorophosphate to produce the photoactive triphosphate, 5-azido-2'-deoxyuridine-5'-triphosphate or 5-azido-dUTP. The photoactive compound, when added to DNA in an in vitro synthesis reaction, produces photoactive DNA. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5945280-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5272055-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6987180-B2 |
| priorityDate | 1985-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.