| abstract |
Compositions containing dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula: <IMAGE> (1) or a pharmaceutically acceptable acid addition salt thereof, wherein n is an integer from 0 to 8; Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond; R1 and R2 are each independently A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH; A2 is -(CH2)qCH(3-r)[(CH2)sOH]r; A3 is -(CH2)qCH(3-r)[(CH2)pCOOR3]r; and A4 is -(CH2)mCOOR3; where m is an integer from 1 to 8; p is an integer from 0 to 4; q is an integer from 0 to 8; r is 2 or 3; s is an integer from 1 to 4; and R3 is H or alkyl of 1 to 18 carbon atoms; R4 is -NO2, -CF3, or halo; and R5 is lower alkyl or -CH2CH2OCH3. Also disclosed are optical isomers of the above compounds, as well as intermediates in the preparation of these final products. |