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filingDate 1985-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1987-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1afbba8603a00c21bf12f07c292e2c90
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publicationDate 1987-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4664892-A
titleOfInvention Biomedical silver-109m isotope generator
abstract A method, composition of matter, and apparatus for producing substantially pure Ag-109m for use in biomedical imaging techniques. Cd-109, which decays with a half-life of 453 days to Ag-109m is loaded onto an ion exchange column consisting of particulate tin phosphate. After secular equilibrium is reached in about ten minutes, Ag-109m may be selectively eluted from the column by means of a physiologically acceptable aqueous buffered eluent solution of sodium thiosulfate, and either ascorbic acid or dextrose. The breakthrough of toxic Cd-109 is on the order of 1×10 -7 , which is sufficiently low to permit administration of the Ag-109m-containing eluate, with but a minor pH adjustment, directly to a human patient within a matter of seconds.
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