http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4664852-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_deff0ab87e07d714dcf3d03223972069 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00 |
| filingDate | 1986-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1987-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ed4ebe8d5e4a6787de20893113c0d62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c95ffbaf45db682ef0b4a92403aeeb80 |
| publicationDate | 1987-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4664852-A |
| titleOfInvention | Process for the preparation of L-carnitine |
| abstract | A process for preparing L-carnitine (I) wherein n (a) diketene (II) is reacted with chlorine, and the chlorination product thus obtained is submitted to amidation by the methylester of an optically-active aminoacid, having formula: ##STR1## wherein R=CH 2 A r or A r wherein Ar is a substituted or not-substituted aromatic group, to yield the compound 4-chloro-3-ketobutyrylamide of the methylester of the optically-active aminoacid: (IV) n (b) the compound (IV) is reduced in the presence of a reducing agent to yield a mixture (V) of (3R)-4-chloro-3-hydroxybutyrylamide of the methylester of an optically-active acid (VI), and (3S)-4-chloro-3-hydroxybutyrylamide of the methylester of an optically active aminoacid (VII), n (c) the compound (VI) is separated and recovered from the reduction reaction product, n (d) the compound (VI) is submitted to methanolysis by hydrogen chloride gas in methanol, n (e) the methylester of the optically-active aminoacid (III) is precipitated and recovered from the methanolysis reaction product, n (f) from the mother liquors the methylester of (3R)-4-chloro-3-hydroxybutyric acid (VIII) is recovered, n (g) the compound (VIII) thus obtained is treated with trimethylamine in ethanol, is hydrolyzed with hydrochloric acid and L-carnitine is separated and recovered. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4895979-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011098477-A1 |
| priorityDate | 1985-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 159.