| abstract |
Antiinflammatory 2-halo-4,5-diarylpyrroles are provided. These pyrroles have the formula: <IMAGE> wherein Y1 is F, Cl, Br, or I; Y2 is H, Cl, or Br; R1 is H, CH3, C2H5, acetyl, or <IMAGE> where R4 is methyl, ethyl, t-butyl, or benzyl; R2 is pyridyl or <IMAGE> R3 is pyridyl or <IMAGE> X and X' are independently H, F, Cl, Br, OR5, or R5S(O)n where n is 0, 1 or 2 and R5 is C1-C2 alkyl; provided that one of R2 or R3 must be <IMAGE> or a pharmaceutically suitable salt thereof. Intermediates to the above pyrroles are provided where R1 in the above formula is replaced by R1 which is benzenesulfonyl or 4-toluenesulfonyl. |