abstract |
This invention relates to novel organic trithio oxides of the formula: R1-X -R-X1-R1 wherein R is selected from -CH2CH=CH-, <IMAGE> and (CH2)3; X is selected from <IMAGE> X1 is selected from -S-S, <IMAGE> and, each R1 is independently selected from carboxyalkyl, alkoxy, alkylthio, amino, alkylamino and acyl substituted and unsubstituted lower alkyl, lower alkenyl, lower alkynyl, phenyl and lower alkylphenyl; provided when R is -CH2CH=CH-, X is <IMAGE> and X1 is -S-S-, then R1 is not in both instances -CH2CH=CH2. This invention also relates to a method of preparing the above-identified compounds by heating and further oxidizing various oxides of organic disulfides and to antithrombotic uses of the compounds. |