http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4616084-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D505-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D503-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C201-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D503-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D505-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C205-42 |
| filingDate | 1984-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13151fa1c8c2b6f0dbb1534c36979c4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45f3bbee1b5a010f65a22934003c9025 |
| publicationDate | 1986-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4616084-A |
| titleOfInvention | Process for the preparation of 7-acylamino-3-hydroxy-cephem-4-carboxylic acids and 7-acylamino-3-hydroxy-1-dethia-1-oxacephem-4-carboxylic acids |
| abstract | A process for the preparation of a 7-acylamino-3-hydroxy-2-cephem-4-carboxylic acid, 7-acylamino-3-hydroxy-1-dethia-1-oxa-3-cephem-4-carboxylic acid or derivative thereof of the general formula ##STR1## in which R 1 is hydrogen or optionally substituted alkyl, alkenyl, alkinyl, aralkyl, aryl, heteroaryl, heteroaralkyl, aryloxyalkyl, heteroaryloxyalkyl, alkoxyalkyl, arylthioalkyl, heteroarylthioalkyl, alkylthioalkyl, alkoxy, aryloxy, alkylthio or arylthio, n R 2 is hydrogen, a carboxy-protective group or a pharmaceutically useful ester radical, and n X is sulphur or oxygen, n which comprises: n (a) reacting a compound of the formula ##STR2## with (i) a compound of the formula ##STR3## in which R 2 and X have the abovementioned meaning and Y represents diazo (N 2 ) or hydrogen (H 2 ) in an inert solvent in the presence of a Lewis acid or proton acid catalyst, or n (ii) a compound of the formula n n HX--CH.sub.2 --C.tbd.C--COOR.sup.2 n n to form an intemediate compound having a triple bond, and hydrating the triple bond, the compounds thus obtained, for Y being hydrogen (H 2 )--(in case of Y=diazo (N 2 ) directly the compounds of general formula (2) are obtained) thereby to produce a compound of the formula ##STR4## (b) reacting such compound with an azide in a solvent in the presence of a base to give a compound of the formula ##STR5## (c) converting said compound to the desired product by (i) irradiation in an inert solvent, or n (ii) warming in the presence of a catalyst. n The end products are, or can be converted to, known β-lactam antibiotics. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009131394-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10239890-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9809605-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9453032-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9862729-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10000509-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883772-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9975905-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011135847-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112452317-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112452317-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11028103-B2 |
| priorityDate | 1983-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 559.