abstract |
The syntheses of 25,26-dehydro-1 alpha ,23S-dihydroxycholecalciferol, 25,26-dehydro-1 alpha ,23R-dihydroxycholecalciferol, and the epimeric mixture thereof which are useful as differentiation inducing agents and anti-proliferation agents are described, 25,26-dehydro-1 alpha ,23S-dihydroxycholecalciferol 25,26-dehydro-1 alpha ,23R-dihydroxycholecalciferol and the epimeric mixture thereof are useful for treating tumors and leukemia, and osteoporosis. |