http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4599423-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a5173a7d063a9f70ca7b5e86fc23863 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 |
| filingDate | 1984-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1986-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc50ea0b690e745243c0055850513558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_162677b7df87b744ac5b3c85665fcf35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85f744ef3dfc46131623a497d6c4e1a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9bcd2944eb1462eebc05273a126a91d |
| publicationDate | 1986-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4599423-A |
| titleOfInvention | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones |
| abstract | Disclosed and claimed is the cardiotonic use of 1-R 1 -5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinones (II), where R 1 is hydrogen, lower-alkyl or lower-hydroxyalkyl, R is lower-alkyl or hydrogen, and, R' and R" are each hydrogen, amino or hydroxy, at least one of R' or R" being other than hydrogen, or where R' is nitro when R" is hydroxy, or pharmaceutically acceptable acid-addition salts thereof where at least one of R' and R" is amino. Also disclosed and claimed are 1-R 1 -5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinones (I), where R 1 , R' and R" are defined as above and R is lower-alkyl and acid-addition salts thereof where at least one of R' and R" is amino. Also shown and claimed is the process which comprises reacting 1-R 1 -1,2-dihydro-2-oxo-5-(3-R'-4-R"-phenyl)-6-R-nicotinonitrile, where R 1 and R are defined as above for II, R' is hydrogen, hydroxy, methoxy or amino and R" is hydroxy, methoxy or hydrogen, preferably at least one of R' and R" being methoxy, or where R' is nitro and R" is hydrogen or methoxy, preferably methoxy, with 85% phosphoric acid to produce 1-R 1 -5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinone, where R 1 and R are defined as above for II, R' is hydrogen, hydroxy or amino and R" is hydroxy or hydrogen, at least one of R' and R" being hydroxy, or where R' is nitro and R" is hydroxy. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE37650-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE36256-E http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633379-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5480883-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5646153-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9296741-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6645969-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5795889-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004014774-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5710158-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5714493-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5721237-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5409930-A |
| priorityDate | 1982-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 509.