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filingDate 1984-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1986-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20600ee46e2d5455cfa9cd81606c7f54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63d9637fd6364030634b76a5aa9a1d3f
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publicationDate 1986-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4588831-A
titleOfInvention Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-naphthoquinone, and process for their production and use
abstract The invention relates to platinum complexes of the following general formula: <IMAGE> (I) wherein R1 and R2 represent alkyl radicals with 1 to 18 carbon atoms, or R1 or R2 represent a hydrogen atom and R2 or R1 can represent an alkyl radical or a <IMAGE> in which R3 is a hydrogen atom or the <IMAGE> radical or an acyl radical, and x=1 or 2. These compounds can be produced by reaction of an alcohol solution of a 5,8-dihydroxyl-1,4-naphthoquinone of the following formula: <IMAGE> (IV) in which the substituents R1 and R2 have the aforementioned meanings, in the presence of a concentrated aqueous ammonia solution, which adjusts the pH over 7, with K2PtCl4 at room temperature. These platinum complex compounds are characterized by a good antitumor effect with low toxicity.
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