| abstract |
4-Substituted proline derivatives having the formula ##STR1## can be prepared by reacting the compound having the formula ##STR2## with a compound having the formula ##STR3## to obtain a compound having the formula ##STR4## (a novel intermediate), alkylating that compound to obtain a compound having the formula ##STR5## (a novel intermediate), converting that compound to a compound having the formula ##STR6## (a novel intermediate), and oxidizing that compound to yield the desired proline having the formula ##STR7## wherein R 1 is alkyl, cycloalkyl, aryl or arylalkyl, R 1 ' is alkyl, cycloalkenyl, aryl or arylalkyl, R 2 is alkyl, aryl, arylalkyl or cycloalkyl and R 3 is hydrogen, alkyl, aryl, arylalkyl or cycloalkyl. |