| abstract |
Quinazoline derivatives of formula: ##STR1## wherein R represents: (1) a straight or branched chain unsaturated hydrocarbon group, or n (2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R is a C 1 hydrocarbon group; or saturated carbocyclic group; or group containing at least one heteroatom, the or each heteroatom being O, N or S when R contains a cyclic group; and n n is O or an integer of 1-4; n X or, when n is an integer of at least 2, each X independently, represents a halogeno, C 1 -C 4 alkyl, aryl or aralkyl group or a group including at least one heteroatom; and n Y represents a group of formula: ##STR2## wherein m≧1 (poly-L-glutamates); and the pharmaceutically acceptable salts and esters thereof, which are suitable as anti-cancer agents. |