| abstract |
Substituted 5H-pyrimido[5,4-b]indoles of Formula I ##STR1## wherein R 2 is halogen; the oxadiazolyl group ##STR2## wherein R" is lower alkyl with up to 3 carbon atoms; C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; OR I , SO n R I with n being 0, 1, or 2, or ##STR3## wherein R I is hydrogen, C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; ##STR4## wherein R II and R III are hydrogen, C 1-5 -alkyl, C 3-5 -alkenyl, cycloalkyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; and n R A is hydrogen; the oxadiazolyl group ##STR5## wherein R" is lower alkyl with up to 3 carbon atoms; halogen, nitro, OR I , SO n R I with n being 0, 1, or 2, ##STR6## wherein R I is hydrogen, C 1-5 -alkyl, cycloalkyl, aralkyl, or aryl; ##STR7## wherein R II and R III are hydrogen, C 1-5 -alkyl, cycloalkyl, C 3-5 -alkenyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; or n n PO(OR).sub.2 n n wherein R is C 1-5 -alkyl, exhibit strong affinity for binding to benzodiazepine receptors. n The novel compounds are suitable for use in psychopharmaceutical preparations. |