| abstract |
Δ 8 ,9 -Prostane derivatives of Formula I ##STR1## wherein R 1 is CH 2 OH or ##STR2## wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, or a heterocyclic residue; or R 1 is ##STR3## wherein R 3 is an acid residue or R 2 ; A is --CH 2 --CH 2 -- or cis--CH═CH; n B is --CH 2 --CH 2 --, trans--CH═CH-- or --C.tbd.C-- n W is a free or functionally modified hydroxymethylene group or free or functionally modified ##STR4## wherein the OH--group can be in the α-- or β-- position; D and E jointly are a direct bond or n D is straight chain or branched alkylene or alkenylene of 1-10 carbon atoms which can optionally be substituted by fluorine atoms, and E is oxygen, sulfur, a direct bond, --C.tbd.C-- or --CR 6 ═CR 7 --, wherein R 6 and R 7 differ from each other and each is hydrogen, chlorine or alkyl; n R 4 is free or functionally modified hydroxy and n R 5 is an optionally substituted aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group, and when R 2 is hydrogen, physiologically compatible salts thereof with bases, n have valuable pharmacological properties, e.g. luteolytic and abortifacient activities. |