| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b339667a9c5df0c16e3d15f595f382c8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K4-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K4-12 |
| filingDate |
1984-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1985-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cdd35f31106772882c1034e9e757ced |
| publicationDate |
1985-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4558057-A |
| titleOfInvention |
Purified antineoplaston fractions and methods of treating neoplastic disease |
| abstract |
Highly purified fractions from human urine exhibiting antineoplastic activity and processes for their preparation are described. The fractions comprise biologically active, small sized, low molecular weight peptides which exert cytostatic and cytotoxic activity toward neoplastic cell cultures and human neoplastic diseases. The fractions have been termed antineoplaston fractions. An antineoplastic active peptide common to each of the various antineoplaston fractions has been isolated and identified as 3-[N-phenylacetylaminopiperidine]-2, 6-dion. A synthetic mechanism for the preparation of 3-[N-phenylacetylaminopiperdine]-2, 6-dion is also disclosed, involving a combination reaction between L-glutamine and phenylacetyl chloride. Also disclosed are the hydrolysis degradation products of 3-[N-phenylacetylaminopiperidine]-2, 6-dion which also exhibit antineoplastic activity when administered according to the general teachings presented in this disclosure. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9116309-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5244922-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006246016-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5646182-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4918193-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4705796-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5238947-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5100807-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019043214-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111278815-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5089508-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-970061867-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/LT-3518-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5254587-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SG-81889-A1 |
| priorityDate |
1981-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |