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publicationDate 1985-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4532020-A
titleOfInvention Process for preparing a β-(fluoroalkyl or fluoroalkenyl)-β-hydroxyalkyne
abstract A process for preparing a beta -(fluoroalkyl or fluoroalkenyl)- beta -hydroxyalkyne represented by the formula <IMAGE> (I) wherein Rf represents a fluoroalkyl or fluoroalkenyl group and R represents an aliphatic or aromatic group, comprising reacting an alkyne represented by the formula R-C 3BOND CH (II) wherein R is the same as defined above with a fluorine containing aldehyde represented by the formula RfCHO (III) wherein Rf is the same as defined above in the presence of catalyst under ultrasonic irradiation. A process for preparing an alpha -(fluoroalkyl or fluoroalkenyl)allyl alcohol represented by the formula <IMAGE> (IV) wherein Rf represents a fluoroalkyl or fluoroalkenyl group, R represents an aliphatic or aromatic group and R' represents a hydrogen atom or an aliphatic group, comprising (1) reacting a beta -(fluoroalkyl or fluoroalkenyl)- beta -hydroxyalkyne represented by the formula <IMAGE> (I) wherein Rf and R are respectively the same as defined above with a isobutylmagnesium halide represented by the formula i-C4H9MgX wherein X represents a halogen atom, and (2) reacting the reaction mixture thus obtained above with a halide represented by the formula R'X' wherein X' represents a halogen atom and R' is the same as defined above.
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