http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4523026-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce40b5a2e78a9c004b676b5ace7fa8f3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0613 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L27-30 |
| filingDate | 1983-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1985-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4945409ce1be7687ce9912ff6f7b5103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a03edf4bd9a76e275293387500227180 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a60c14bde3c435ee4a71b98bc70ad36 |
| publicationDate | 1985-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4523026-A |
| titleOfInvention | Synthesis of N-benzyloxycarbonyl-L-aspartic acid |
| abstract | N-Benzyloxycarbonyl-L-aspartic acid (Z-Asp) is synthesized by adding benzyl chloroformate to a solution of L-aspartic acid and sodium hydroxide at relatively high temperatures of 35 DEG -55 DEG C. and over a wide pH range of 9.2-12.0 and acidifying the sodium salt product. The Z-Asp is prepared in high yields exceeding 90% and purity of better than 99% with only a minor amount of the by-product N-benzyloxycarbonyl aspartyl aspartic acid. The Z-Asp is suitable for conversion to aspartame. Carrying out the reaction at high temperatures significantly reduces cycle time while maintaining a high yield with a low dipeptide and unreacted L-aspartic acid content. |
| priorityDate | 1983-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.