| abstract |
N,N'-substituted polymethylene diamines of the formula: ##STR1## in which: A is a hydrocarbon radical from C 3 to C 5 in a straight or branched chain optionally containing one and two double bonds and possibly substituted by one or more hydroxy radicals; n X is CH or nitrogen; n n is an integer from 2 to 6; n R 1 is hydrogen, or alkyl from C 1 to C 5 ; n R 2 is hydrogen, alkyl from C 1 to C 5 , cycloalkyl from C 5 to C 7 , or phenyl optionally substituted by one or more fluorine or chlorine, and n B is: n phenyl, naphthyl, benzofuranyl, benzothionyl, benzodioxolyl, benzodioxanyl, benzodioxinyl, Δ3-chromenyl, thiochromenyl or chromanyl, each of them optionally substituted by fluorine, chlorine, alkyl or alkoxy from C 1 to C 5 , or methylene-dioxy, or n a radical of the formula: ##STR2## in which R 3 , R 4 and R 5 which may be the same or different, each represent hydrogen or phenyl optionally substituted by fluorine or chlorine. n These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of all kinds of tissular hypoxia. |