| abstract |
PCT No. PCT/JP82/00012 Sec. 371 Date Sep. 13, 1982 Sec. 102(e) Date Sep. 13, 1982 PCT Filed Jan. 13, 1982 PCT Pub. No. WO82/02383 PCT Pub. Date Jul. 22, 1982.The present invention provides new thiazole compounds possessing immuno-modulating activity, i.e. thiazole compounds of the general formula (1): <IMAGE> (1) wherein R1 stands for a hydrogen or halogen atom or a lower alkyl, lower alkoxy, substituted or unsubstituted phenoxy, nitro or cyano group, R2 for a hydrogen atom or a lower alkyl or lower alkylthio group, and R for an alpha -halogenoalkyl group or the grouping: <IMAGE> a process for preparing same and pharmaceutical compositions containing the thiazole compounds. More particularly, the present invention provides new thiazole compounds of the above general formula (1) which have immuno-modulating activity and are thus effective against immunodiseases such as chronic rheumatoid arthritis and also useful against viral diseases or for the immunotherapy of cancers, but show weak toxicity and are thus extremely desirous as medicines, a process for the preparation of the thiazole compounds and pharmaceutical compositions containing the thiazole compounds. |