http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4501696-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a8659631bf38b3a590c0d3edc265492c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-21 |
| filingDate | 1982-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1985-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f695b3f6fd606595b4d126eb2b686951 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90593eae142b452f3fe02ed340d9452c |
| publicationDate | 1985-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4501696-A |
| titleOfInvention | Process for the preparation of penam derivatives |
| abstract | A process for the preparation of a penam derivative of formula (I): ##STR1## wherein R A is hydrogen or a group of formula (Ia): ##STR2## wherein X is --CO 2 R 1 , or SO 3 R 1 ; R is C 1-6 alkyl, aryl, or heterocyclyl; R 1 is hydrogen, or a pharmaceutically acceptable salt-forming ion or ester-forming radical, and R 2 represents hydrogen or a pharmaceutically acceptable salt-forming ion or in vivo hydrolyzable ester-forming radical; which process comprises reacting a compound of formula (II): ##STR3## wherein R B is hydrogen, a removable amino blocking group, or a group of formula (IIa): ##STR4## wherein Y is --CO 2 R x or --SO 3 R x ; R is as defined with respect to formula (I) above; R x represents an ester-forming radical, R Y represents hydrogen, a salt-forming radical or a carboxyl-blocking group, and R 3 represents an alkyl, benzyl, or aryl group; with methanol in the presence of copper ions; and thereafter if necessary carrying out one or more of the following steps: n (i) removal of any blocking group; n (ii) converting the product to a pharmaceutically acceptable salt or ester thereof. |
| priorityDate | 1981-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.