abstract |
7 alpha -acylthio-15,16-methylene-3-oxo-17 alpha -pregna-1,4-diene-21,17-carbolactones of the formula <IMAGE> wherein the 15,16-methylene group can be in the alpha - or beta -configuration, and R is a lower alkyl residue, have altialdosterone activity. They are prepared from corresponding DELTA 4-unsaturated compounds by chemical or microbiological 1,2-dehydrogenation. |