| abstract |
Compounds are disclosed of general formula <IMAGE> where R is H, C1-6 alkyl optionally substituted by C3-7 cycloalkyl, C3-6 alkenyl or alkynyl, C3-7 cycloalkyl, aralkyl or -CHO and the physiologically acceptable salts thereof. The compounds have selective alpha 2-adrenoreceptor antagonist action and are indicated as potentially useful for the treatment or prevention of migraine, thrombosis, diabetes, obesity, hypertension, constipation, paralytic ileus, senile dementia and analepsis, and for use in appetite suppression and for the treatment of depression; they may be formulated as pharmaceutical compositions in conventional manner. The compounds may be prepared, for example, by amination of a compound of formula <IMAGE> where X is a leaving group such as halogen or a hydrocarbylsulphonyloxy group. |