| abstract |
2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 has the structural formula <IMAGE> Derivatives thereof have the structural formulas <IMAGE> where A+ are alkali metals, monoethanolamine, diethylamine. <IMAGE> where R is OH, alkyloxyl C 1-4, NHR1, where R1 is H, alkyl C 1-4, phenyl, aralkyl. A are salts of inorganic acids <IMAGE> where R is alkyloxyl C 1-4, NHR', where R' is alkyl C 1-4. A method of producing 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 and derivatives thereof consists in that 2,4-dichloropyrimidine is brought into interaction with anthranilic acid, or a sodium salt of anthranilic acid, or substituted esters, or amides of anthranilic acid in an aqueous medium, or in an organic solvent at a temperature of 90 DEG to 120 DEG C., is kept at this temperature for 1 to 4 hours, and an end product is separated using a conventional method. A chemotherapeutic antiphlogistic, containing as an acting source 2-(o-carboxyphenylamino)-6H-pyrimido(2,1-b)-quinazolone-6 or derivatives thereof, and a pharmaceutical basic material. |