http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4454291-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-42 |
| filingDate | 1982-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ec2629fa43276ef497590c7faefc7d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_619382e994b7fae71c082df3e550118b |
| publicationDate | 1984-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4454291-A |
| titleOfInvention | N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives |
| abstract | Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substituted on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3-phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiotensin converting enzyme and as antihypertensive agents. The compounds of the invention (excluding disclosed intermediates) have the general formula: <IMAGE> wherein: n is 1 or 0; R1 is hydrogen, lower alkyl, aryl or aralkyl; R2 is hydrogen or lower alkyl; R3 is hydrogen, lower alkyl or aroyl; R5 is hydroxy, amino, or lower alkoxy; X is hydrogen, hydroxy, lower alkyl, lower alkoxy, or halogen; Y is hydrogen, lower alkyl, or aryl; Y is hydrogen, lower alkyl, or aryl; R4 is <IMAGE> +TR <IMAGE> wherein: L is O, NR7 or S (where R7 is hydrogen or lower alkyl); M is R8, OR8, SR8, or NR9R10 (where R8 is hydrogen, lower alkyl, aryl, or aralkyl; and R9 and R10 are, independently, hydrogen, lower alkyl, or aryl); A is O, NR13 or S; R11 and R12 are, independently, hydrogen, alkyl, aralkylor aryl; R13 is hydrogen or lower alkyl; m is 0, 1, 2, or 3; R20 is hydrogen or aryl; and R21 is hydroxy or lower alkoxy; or pharmaceutically acceptable salts thereof. Claimed compounds are intermediates of the formula: <IMAGE> wherein R13 is hydrogen or lower alkyl; R14 is R5 or OZ, where R5 is hydroxy, amino, or lower alkoxy, and Z is a carboxylic acid protecting group. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-582233-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4578480-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005031604-A1 |
| priorityDate | 1981-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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