| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e77f06144be4708a6ae75bd9fee56a4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J13-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0022
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J43-003 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 |
| filingDate |
1982-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1984-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_458f5773670fe38dd9e65ddef42625ba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_353a56570274d9d58e5d2c8c58dda65e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f56c2ef9b46a87bc9b58c63b1bd3b0b |
| publicationDate |
1984-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-4447425-A |
| titleOfInvention |
Mono- and bisquaternary ammonium derivatives of 2β,16β-di-amino-5α-androstane derivatives and pharmaceutical preparations containing same |
| abstract |
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5 alpha -androstanes having the formula: <IMAGE> wherein: R1=H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the N-atom a piperidino, pyrrolidino or morpholino group; R4=O or H( beta OR5) and R5=H or acyl derived from an organic carboxylic acid having 1-18, preferably 1-6 carbon atoms; the quaternarizing group being a saturated or unsaturated aliphatic hydrocarbon group having 1-4 carbon atoms the anion being halide; and acid addition salts of the monoquaternary compounds; and to pharmaceutical preparations containing one or more of said androstane compounds as active constituent. The compounds according to the invention are non-depolarizing neuromuscular blocking agents having very quick onset and recovery characteristics, a short duration of action and a favorable dissociation between muscle blocking and vagal blocking effects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6090957-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009093632-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009137794-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5808051-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7569687-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5817803-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7642246-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5521167-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007117975-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4894369-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007265237-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-724696-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5593983-A |
| priorityDate |
1981-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |