| abstract |
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R 1 and R 2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the other is alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, mono-, di- or trifluoroalkyl, cyanoalkyl, alkanoylalkyl or ##STR2## wherein n is 1, 2, 3 or 4 and Y 1 and Y 2 are the same or different and each is hydrogen or alkyl; n R 3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or fluorine; n R 4 is carbonyl, β-hydroxymethylene or β-acetyloxymethylene; n R 5 is hydrogen or halogen; and n R 6 is hydrogen, methyl, hydroxy, alkanoyl, alkanoyloxy or halogen. |