http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4424355-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-14 |
| filingDate | 1982-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1984-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c56ca7bef7d6c67b607af57a8b90a1ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d1ad9d6dfc2a359f2917bba80bd6216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cce04d1ce059748b3ad335d884bb6c65 |
| publicationDate | 1984-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4424355-A |
| titleOfInvention | Resolution of substituted dibenzo b,f!thiepin-3-carboxylic acid-5-oxides with brucine or ephedrine |
| abstract | The present invention is concerned with an improved process for the production of highly active optical isomers of (-) 7 or 8 fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide having the structural formula ##STR1## in which the fluoro substituent replaces a hydrogen in the 7 or 8 position. The two active isomers represented by formula II are S(-)7-fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide and R(-)8-fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide. It is especially concerned with the resolution of the racemic 7 or 8 fluorodibenzo b,f!thiepin-3-carboxylic acid-5-oxide by first forming and separating diastereomers of said racemic carboxylic acids by salt formation with brucine or ephedrine followed by crystallization and regeneration of the desired (-) isomers and recycling of the (+) isomer by racemization of the regenerated isomer. The compounds obtained in high yield by this process are highly active prostaglandin antagonists which are useful in treating a variety of conditions such as allergic asthma. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9925849-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4558037-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011019391-A1 |
| priorityDate | 1981-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.