| abstract |
The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof. The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a <IMAGE> and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b <IMAGE> and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, <IMAGE> if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention can be used in therapy in the treatment of psoriasis. |