http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4419347-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b4beef0c137d9094e6918ee382be22f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-23 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23 |
| filingDate | 1982-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1983-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db73f4f1be7e112d30160d72e024bc92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f9dae6fadb57a6cf3f3831995f0a329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d01f5e6da8b85649c2a0dfef44d771b1 |
| publicationDate | 1983-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-4419347-A |
| titleOfInvention | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| abstract | Nonapeptide and decapeptide analogs of LHRH which have the formula <IMAGE> (I) and the pharmaceutically acceptable salts thereof, wherein: X is a D-alanyl residue wherein one hydrogen on C-3 is replaced by: (a) a carbocyclic aryl-containing radical selected from the group consisting of phenyl substituted with three or more straight chain lower alkyl groups, naphthyl, anthryl, fluorenyl, phenanthryl, biphenylyl and benzhydryl; or (b) a saturated carbocyclic radical selected from the group consisting of cyclohexyl substituted with three or more straight chain lower alkyl groups, perhydronaphthyl, perhydrobiphenylyl, perhydro-2,2-diphenylmethyl, and adamantyl; or (c) a heterocyclic aryl containing radical selected from the group consisting of radicals represented by the following structural formulas: <IMAGE> <IMAGE> <IMAGE> wherein A'' and A' are independently selected from the group consisting of hydrogen, lower alkyl, chlorine, and bromine, and G is selected from the group consisting of oxygen, nitrogen, and sulfur; A is an aminoacyl residue selected from the group consisting of L-pyroglutamyl, D-pyroglutamyl, N-acyl-L-prolyl, N-acyl-D-prolyl, N-acyl-D-tryptophanyl, N-acyl-D-phenylalanyl, N-acyl-D-p-halophenylalanyl, and N-acyl-X wherein X is as defined previously; B is an amino acyl residue selected from the group consisting of D-phenylalanyl, D-p-halophenylalanyl, 2,2-diphenylglycyl, and X wherein X is as defined previously; C is an amino acyl residue selected from the group consisting of L-tryptophanyl, D-tryptophanyl, D-phenylalanyl and X wherein X is as defined above; E is glycinamide or -NH-R1, wherein R1 is lower alkyl, cycloalkyl, fluoro lower alkyl or <IMAGE> wherein R2 is hydrogen or lower alkyl; are disclosed. These compounds are LHRH antagonists. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5767082-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5036047-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4801577-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4762717-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5843901-A |
| priorityDate | 1980-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 397.