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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38
filingDate 1981-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_612444f7f1f43e10f3d454c65649fd72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cad7f0be14eb962aacd4b921ecfadee1
publicationDate 1983-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4418019-A
titleOfInvention Process for the manufacture of 1-aminoalkane-1,1-diphosphonic acids
abstract The invention relates to a process for making 1-aminoalkane-1,1-diphosphonic acids of the general formula (I): <IMAGE> (I) in which R stands for an aliphatic hydrocarbon radical having from 1 to 12 carbon atoms. To this end, the invention provides: (a) for tetraphosphorus hexoxide to be reacted with at least one compound of the general formula (II) <IMAGE> (II) in which R has the meaning given above and X stands for an -ONH4 or NH2-radical, in inert gas atmosphere at elevated temperature, the molar ratio of tetraphosphorus hexoxide to the compound of general formula (II) being about 1 to 2-6; and (b) for 1-aminoalkane-1,1-diphosphonic acid to be crystallized from the reaction mixture.
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