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filingDate 1981-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6aa91066aaf1f3db7cfb987bed4b057a
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publicationDate 1983-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4413056-A
titleOfInvention Process for the preparation of penicillins and penicillin derivatives
abstract A process for the preparation of a compound of formula (I): <IMAGE> (I) wherein R1 is hydrogen, hydroxy, mercapto radical, a substituted or unsubstituted methoxy, ethoxy, methyl, ethyl, methyl thio, or ethylthio radical, a carbamoyloxy, carbamoylthio, C1-6 alkanoyloxy, C1-6 alkanoylthio, cyano, carboxy or carbamoyl radical; and R2 represents an acyl group which comprises hydrolysis of a compound of formula (II): <IMAGE> (II) wherein R1 and R2 are as defined with respect to formula (I) hereinbefore and R3 represents benzyl or substituted benzyl; wherein the hydrolysis is catalyzed by a microbial serine proteinase.
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