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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01
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filingDate 1981-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cff0cd0e8a90c50656f2f5cd26055279
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad9e9f3236a64d6f61053e366c0036e8
publicationDate 1983-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4408059-A
titleOfInvention Spiroketals useful as intermediates in the synthesis of milbemycin and avermectin macrolides
abstract Milbemycin and avermectin macrolides are synthesized by the cyclized linking of separately synthesized northern and southern hemisphere intermediates. The northern hemisphere intermediate is a spiroketal alkenyl aldehyde, and the southern hemisphere intermediate is an aryl alkenyl phosphine oxide anion.
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