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filingDate 1982-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1983-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1983-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-4407804-A
titleOfInvention Analgesic mixture of nalbuphine and indomethacin
abstract Pharmaceutical compositions of nalbuphine and indomethacin have been found to exhibit unexpectedly enhanced analgesic activity by applying an analysis model which considers data characterizing the analgesic effect of both the pure components as well as the fixed dose ratio combinations. This synergism enables the use of lower doses of either or both drugs with a concomitant reduction in risk of possible side effects.
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